Breaking News item – Immunopaedia

With great interest I read about the new insights regarding the role of type I interferon in severe COVID-19 disease. Diminished IFN-I production, inborn errors in regulation of the IFN-I response and the production of neutralizing IFN-I autoantibodies could play a role in severe COVID-19 disease in patients outside of the typical risk group.
I briefly highlighted these new findings in a breaking news item on
Immunopaedia, a website promoting immunology education worldwide.


JoLS initiative mentioned by US National Postdoc Association

Our initiative of the Journal of Life Science (JoLS) is highlighted by the US National Postdoc Association

JoLS is the first of its kind—a journal entirely run by postdoctoral scholars from universities and research institutes across the world.

Together, JoLS members have built a unique and independent platform to support and enhance the postdoctoral experience in the life sciences. In addition to publishing high-quality articles, the journal offers abundant learning opportunities to new postdoctoral trainees, promising graduate and undergraduate students—including participation in scientific writing, peer-reviewing and editing—that wish to build a compelling scientific resume




Completed the Science Mentoring Workshop

Science Mentoring 3-part workshop for graduate students and postdoctoral fellows who are mentoring undergraduates in the laboratory or field.

Part 1. Undergraduate Research Fellowships & Writing Recommendation Letters / Developing Research Projects with Undergraduates/Diversity and Inclusion

Part 2. Mentoring Undergraduates: Handling Challenges,/Celebrating Successes/Diversity and Inclusion/Supporting Student Science Writing

Part 3. Undergraduate Researcher Panel Q&A

Workshop info – link


Article in Cell Reports by lab colleague Cees van der Poel

Article by lab colleague Cees van der Poel entitled “Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcgRIIB” is published in Cell reports (open access).

• Stromal FcγRIIB deficiency causes increased germinal center diversity
• Absence of FcγRIIB on Follicular Dendritic Cells (FDCs) supports persistence of low Somatic HyperMutation (SHM) B cell clones

Cell Reports 2019 C van der Poel

Class-switch recombination (CSR) of antibodies occurs prior to germinal center formation.

With great interest I’ve read the recent publication in Immunity that alters our current understanding of when class switch recombination (CSR) occurs. It was always believed that CSR and Somatic Hyper Mutation (SHM) occurred within the germinal center, but Roco et al. show that CSR actually occurs prior to germinal center formation and extrafollicular plasmablast induction. Signs of CSR can be detected as early as 1.5 days following immunization. This result explains why many IgM memory B cells can be found, as if CSR occured in the germinal center they would likely be skewed towards the same isotype. Overall, this new insight alters our current dogma of when we believe CSR occurs and opens up a specific window of when we could specifically intervene with CSR.

I briefly highlighted this new finding in a breaking news item on Immunopaedia, promoting immunology education worldwide.