T:B cell interactions in lymphoid structures
– aiming to drive meaningful clinical advancements –
Center for Translational Immunology, UMC Utrecht
Utrecht, the Netherlands
T:B cell lab
Linking human T and B cell biology to disease mechanisms and clinical translation.
Our team is dedicated to understanding human T:B cell interactions, especially within lymphoid structures of the developing pediatric immune system and in chronic inflammation. By exploring these contexts, we aim to elucidate T:B cell interaction processes and contribute to disease resolution and prevention.
About the lab
The lab is part of the Center for Translational Immunology (CTI), which brings together leading immunology expertise to conduct all immunological disease research at University Medical Center Utrecht.
Located in the Wilhelmina Children’s Hospital next to UMC Utrecht and the Princess Maxima Center, the lab benefits from access to diverse clinical samples, enhancing translational research opportunities across diseases and enabling close collaboration with clinicians to improve diagnostics and patient outcomes.
News
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ZonMw Open Competition Grant
The ZonMw Open Competition gives research teams the space to explore new ideas and work together, leading to high-quality, groundbreaking research. It encourages collaboration and allows researchers to study important questions without fixed themes. This project team consists of: Theo van den Broek (UMC Utrecht), Virgil Dalm (Erasmus MC, coordinator), Ines da Silva Serra (Erasmus…
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Lab Collaboration Results in Publication in ‘Inflammatory Bowel Diseases’
This study explores how autologous hematopoietic stem cell transplantation (aHSCT) reshapes the immune system in people with severe Crohn’s disease who do not respond to conventional treatments. Tracking patients for up to two years, the researchers found strong changes in circulating T cells after transplantation, particularly in those who improved clinically. Interestingly, immune changes in…
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Associate member of Centre for Complex Systems Studies (CCSS)
Thrilled to share that I’ve been admitted as an Associated Member of CCSS. Our work on emergent T–B cell dynamics in human lymphoid structures sits naturally at the interface of immunology and complex systems science, and I’m excited to engage with the CCSS community, bring new complex perspectives into our experimental work, and contribute to…
T:B Cell lab 