T:B cell interactions in lymphoid structures
– aiming to drive meaningful clinical advancements –
Center for Translational Immunology, UMC Utrecht
Utrecht, the Netherlands
T:B cell lab
Linking human T and B cell biology to disease mechanisms and clinical translation.
Our team is dedicated to understanding human T:B cell interactions, especially within lymphoid structures of the developing pediatric immune system and in chronic inflammation. By exploring these contexts, we aim to elucidate T:B cell interaction processes and contribute to disease resolution and prevention.
About the lab
The lab is part of the Center for Translational Immunology (CTI), which brings together leading immunology expertise to conduct all immunological disease research at University Medical Center Utrecht.
Located in the Wilhelmina Children’s Hospital next to UMC Utrecht and the Princess Maxima Center, the lab benefits from access to diverse clinical samples, enhancing translational research opportunities across diseases and enabling close collaboration with clinicians to improve diagnostics and patient outcomes.
News
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Science Jam #65 (CCSS): The Complexity Behind Effective Immune Responses
Thanks to the Young Complexity Researchers Utrecht (YCRU) group, they brought these popular sessions back to the CCSS for our researchers to discuss challenges in Complex Systems Studies. Everyone is welcome! Abstract of presentation:The adaptive immune system protects against infection by generating highly specific and long-lasting responses. Germinal centers (GCs) are the sites where high-affinity antibody…
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ZonMw Open Competition Grant
The ZonMw Open Competition gives research teams the space to explore new ideas and work together, leading to high-quality, groundbreaking research. It encourages collaboration and allows researchers to study important questions without fixed themes. This project team consists of: Theo van den Broek (UMC Utrecht), Virgil Dalm (Erasmus MC, coordinator), Ines da Silva Serra (Erasmus…
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Research Collaboration Published in ‘Journal of Clinical Investigation’
In early life, newborns are exposed to many new antigens, and their immune system must learn to tolerate harmless substances while still defending against threats. This study shows that naïve CD4+ T cells in newborns are especially good at becoming regulatory T cells (Tregs), which help maintain immune tolerance. This enhanced ability is linked to…
T:B Cell lab 