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I try to publish my research findings as much I can in open access. However, some scientific publishers charge outrageous fees to make our research public. Therefore, some of my publications remain behind the publisher’s paywall. Should you desire access to those papers, please send your request for a copy through my ResearchGate page, or send me an email.


T. van den Broek, F. Miedema, BJ. Prakken
Prepare PhD holder for diferent career tracks
Nature 2021, Dec 14; 600 (7889), 386
doi: 10.1038/d41586-021-03695-w. PubMed PMID: 34907397

Akama-Garren E., van den Broek T.*, Simoni L.*,  Castrillon C., van der Poel CE,  Carroll MC. (* contributed equally)
Follicular T Cells are Clonally and Transcriptionally Distinct in B Cell-Driven Mouse Autoimmune Disease
Nature communications, 2021 Nov 18;12(1):6687. doi:10.1038/s41467-021-27035-8. PubMed PMID: 34795279, PMCID: PMC8602266 . Download [PDF]

T. van den Broek
Training during a pandemic
Cell Reports Medicine, Volume 2, Issue 4, April 20, 2021. PubMed PMID: 33948585
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T. van den Broek.
How I started a journal for postdoctoral researchers
Nature. 10 dec (2020). PubMed PMID: 33303983

T. van den Broek, J Gould.
Coronavirus: postdoc winners need paid extensions
Nature.  Jul;583 (7816) :360 (2020). PubMed PMID: 32665630

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van der Poel CE, Bajic G, Macaulay CW, van den Broek T, Ellson CD, Bouma G, Victora GD, Degn SE, Carroll MC.
Follicular Dendritic Cells Modulate GerminalCenter B Cell Diversity through FcgRIIB.
Cell Reports. 29, 2745–2755, November 26, 2019. PubMed PMID: 31775042 Download: [PDF + Suppl data]

van den Broek T, Janssen NG, Hetem DJ, Bekers W, Kamst M, Fluit AC, van INgen J, Kusters JG, Rentenaar RJ.
INNO-LiPA DNA line probe assay misidentification of M. smegmatis as Mycobacterium fortuitum complex.
Diagnostic Microbiology & Infectious Disease, Vol 95, Issue 3, November 2019:114858. doi: 10.1016/j.diagmicrobio.2019.06.010. PubMed PMID: 31358343

van den Broek T.
Road to HIV cure: from Berlin to London and beyond
Journal of Life Sciences (JoLS). Vol. 1, No.1, June 2019, p1-3.

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van den Broek T, Borghans J.A.M., van Wijk F.
The full spectrum of human naïve T cells.
Nat Rev Immunol. 2018. Jun;18(6):363-373. PubMed PMID: 29520044.

       Opinion article in The Scientist. “We have been naive about naive T cells”

van den Broek T.
Changing science, the next time around
Postdoc Journal. Vol. 6, No. 9, September 2018.

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van den Broek T, Madi A, Delemarre EM, Schadenberg AWL, Tesselaar K, Borghans JAM, Nierkens S, Redegeld FA, Otten HG, Rossetti M, Albani S, Sorek R, Cohen IR, Jansen NJG, van Wijk F. PDF
Human neonatal thymectomy induces altered B-cell responses and autoreactivity.
Eur J Immunol. 2017 Nov;47(11):1970-1981. doi: 10.1002/eji.201746971.
PubMed PMID: 28691750; PubMed Central PMCID: PMC5697610.  Download: [PDF] [Suppl data]


Kassa D, Ran L, de Jager W, van den Broek T, Jacobi R, Mekonen M, Messele T, Haks MC, Ottenhoff TH, van Baarle D.
Discriminative expression of whole blood genes in HIV patients with latent and active TB in Ethiopia.
Tuberculosis (Edinb). 2016 Sep; 100:25-31. doi: 10.1016/ PubMed PMID: 27553407.

van den Broek T, Delemarre EM, Janssen WJ, Nievelstein RA, Broen JC, Tesselaar K, Borghans JA, Nieuwenhuis EE, Prakken BJ, Mokry M, Jansen NJ, van Wijk F.
Neonatal thymectomy reveals differentiation and plasticity within human naive T cells.
J Clin Invest. 2016 Mar 1;126(3):1126-36. doi: 10.1172/JCI84997. PubMed PMID: 26901814; PubMed Central PMCID: PMC4767338.

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Delemarre EM*, van den Broek T*, Mijnheer G, Meerding J, Wehrens EJ, Olek S, Boes M, van Herwijnen MJ, Broere F, van Royen A, Wulffraat NM, Prakken BJ, Spierings E, van Wijk F. (*contributed equally)
Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells.
Blood. 2016 Jan 7;127(1):91-101. doi: 10.1182/blood-2015-06-649145
. PubMed PMID: 26480932.

Download: [PDF]  [Suppl data]

     Highlighted in:
     Nat Rev Rheum (2015, Nov; 11: p681) HSCT-resetting immune tolerance by boosting Treg cell diversity. PMID: 26526646.
     Blood (2016, Jan 7;127(1): p8-10) Rebooting autoimmunity with autologous HSCT. PMID: 26744435. Download: [PDF]


Swart JF, de Roock S, Hofhuis FM, Rozemuller H, van den Broek T, Moerer P, Broere F, van Wijk F, Kuis W, Prakken BJ, Martens AC, Wulffraat NM.
Mesenchymal stem cell therapy in proteoglycan induced arthritis.
Ann Rheum Dis. 2015 Apr;74(4):769-77. doi: 10.1136/annrheumdis-2013-204147
. PubMed PMID: 24395558.

van den Broek T, Hoppenreijs E, Meerding J, Scholman R, Otten HG, Swart JF, Martini A, Prakken B, de Jager W.
Cytokine profiling at disease onset: support for classification of young antinuclear antibody-positive patients as a separate category of juvenile idiopathic arthritis.
Ann Rheum Dis. 2015 Feb;74(2):470-2. doi: 10.1136/annrheumdis-2014-206424. PubMed PMID: 25384964.


Audia S, Rossato M, Santegoets K, Spijkers S, Wichers C, Bekker C, Bloem A, Boon L, Flinsenberg T, Compeer E, van den Broek T, Facy O, Ortega-Deballon P, Berthier S, Leguy-Seguin V, Martin L, Ciudad M, Samson M, Trad M, Lorcerie B, Janikashvili N, Saas P, Bonnotte B, Radstake TR.
Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia.
Blood. 2014 Oct 30;124(18):2858-66. doi: 10.1182/blood-2014-03-563445.
PubMed PMID: 25232056.

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Spreafico R*, Rossetti M*, van den Broek T, Jansen NJ, Zhang H, Moshref M, Prakken B, van Loosdregt J, van Wijk F, Albani S. (* contributed equally)
A sensitive protocol for FOXP3 epigenetic analysis in scarce human samples.
Eur J Immunol. 2014 Oct;44(10):3141-3. doi: 10.1002/eji.201444627.
PubMed PMID: 25042685.

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Delemarre EM*, Roord ST*, van den Broek T, Zonneveld-Huijssoon E, de Jager W, Rozemuller H, Martens AC, Broere F, Wulffraat NM, Glant TT, Prakken BJ, van Wijk F. (*contributed equally)
Autologous stem cell transplantation restores immune tolerance in experimental arthritis by renewal and modulation of the Teff cell compartment.
Arthritis Rheumatol. 2014 Feb;66(2):350-6. doi: 10.1002/art.38261.
PubMed PMID: 24504807; PubMed Central PMCID: PMC4131556.

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Schadenberg AW, van den Broek T, Siemelink MA, Algra SO, de Jong PR, Jansen NJ, Prakken BJ, van Wijk F.
Differential homeostatic dynamics of human regulatory T-cell subsets following neonatal thymectomy.
J Allergy Clin Immunol. 2014 Jan; 133(1): 277-80.e1-6. doi: 10.1016/j.jaci.2013.08.030. PubMed PMID: 24139831.

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de Jong PR*, Schadenberg AW*, van den Broek T, Beekman JM, van Wijk F, Coffer PJ, Prakken BJ, Jansen NJ. (* Contributed equally)
STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass.
PLoS One. 2012;7(4):e35070. doi: 10.1371/ journal.pone.0035070.
PubMed PMID: 22506067; PubMed Central PMCID: PMC3323636.

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Puga Yung GL, Fidler M, Albani E, Spermon N, Teklenburg G, Newbury R, Schechter N, van den Broek T, Prakken B, Billetta R, Dohil R, Albani S.
Heat shock protein-derived T-cell epitopes contribute to autoimmune inflammation in pediatric Crohn’s disease.
PLoS One. 2009 Nov 2;4(11):e7714. doi: 10.1371/journal.pone.0007714.
PubMed PMID: 19888320; PubMed Central PMCID: PMC2765612.

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Koffeman EC, Genovese M, Amox D, Keogh E, Santana E, Matteson EL, Kavanaugh A, Molitor JA, Schiff MH, Posever JO, Bathon JM, Kivitz AJ, Samodal R, Belardi F, Dennehey C, van den Broek T, van Wijk F, Zhang X, Zieseniss P, Le T, Prakken BA, Cutter GC, Albani S.
Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial.
Arthritis Rheum. 2009 Nov;60(11):3207-16. doi: 10.1002/art.24916. PubMed PMID: 19877047.

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van den Broek T, Bulk S, Pruijs JE, Beek FJ.
Radiological “bone within a bone” appearance with atraumatic fractures.
Postgrad Med J. 2009 Oct;85(1008):514. doi: 10.1136/pgmj.2008.075382
. PubMed PMID: 19789189.

van den Broek T, Lalezari F, Brouwers HA, Beek FJ.
Unilateral thymus displacement.
JBR-BTR. 2009 May-Jun;92(3):174-5. PubMed PMID: 19670585.

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van den Broek T, Tesser JR, Albani S.
The evolution of biomarkers in rheumatoid arthritis: from clinical research to clinical care.
Expert Opin Biol Ther. 2008 Nov;8(11):1773-85. doi: 10.1517/14712598.8.11.1773. PubMed PMID: 18847311.

Hellings WE, Pasterkamp G, Verhoeven BA, de Kleijn DP, de Vries JP, Seldenrijk CA, van den Broek T, Moll FL.
Differences between men and women in the composition of atherosclerotic plaque, as an explanation for the lower success rate of carotid endarterectomy in women.
Ned Tijdschr Geneeskd. 2008 Nov 29;152(48):2624-31
. (Dutch). PubMed PMID: 19102439.

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Rodriguez-Feo JA, Hellings WE, Moll FL, De Vries JP, van Middelaar BJ, Algra A, Sluijter J, Velema E, van den Broek T, Sessa WC, De Kleijn DP, Pasterkamp G.
Caveolin-1 influences vascular protease activity and is a potential stabilizing factor in human atherosclerotic disease.
PLoS One. 2008 Jul 2;3(7):e2612. doi: 10.1371/journal.pone.0002612. PubMed PMID: 18596970; PubMed Central PMCID: PMC2432041.

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van den Broek T, Liqui Lung PF, Suttorp MJ, Eefting FD, Schipper ME, Vink A.
Vascular occlusion as a late complication of the Angio-Seal closure device. A review of literature.
Minerva Cardioangiol. 2007 Dec;55(6):815-9
. PubMed PMID: 18091648.

van den Broek T., Lazelari F., Brouwers H.A.A., Beek F.J.A.
Unilateral Thymic Deviation.
Radiological Documents, issue 3 2007

van den Broek T, Liqui Lung PF, Suttorp MJ, Eefting FD, Schipper ME, Vink A.
Arterial occlusion after repetitive angio-seal device closure.
Vasc Endovascular Surg. 2007 Aug-Sep;41(4):346-7.
PubMed PMID: 17704339.

Hellings WE, Pasterkamp G, Verhoeven BA, De Kleijn DP, De Vries JP, Seldenrijk KA, van den Broek T, Moll FL.
Gender-associated differences in plaque phenotype of patients undergoing carotid endarterectomy.
J Vasc Surg. 2007 Feb;45(2):289-96; discussion 296-7. PubMed PMID: 17264005.

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       Highlighted in:
       J Vasc Surg. (2007, Feb; 45(2):296-297) invited commentary.


Hellings WE, Verhoeven BA, Moll FL, van den Broek T, Pasterkamp G.
Pathophysiology of gender difference in prognosis of asymptomatic carotid stenosis: research and future implications.
Stroke. 2006 Feb;37(2):332. PubMed PMID: 16397166.

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van den Broek T.
De ontwikkeling van de hart-long machine
Ned Tijdschr Geneeskd (s) 2005 september;8(3) p47-49 (Dutch).

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van den Broek T.
Betere Test op Prostaatkanker.
Medisch contact 2005; 44:1773

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